General Information

  • ID:  hor002910
  • Uniprot ID:  P67858
  • Protein name:  Proctolin
  • Gene name:  NA
  • Organism:  Limulus polyphemus (Atlantic horseshoe crab)
  • Family:  NA
  • Source:  Animal
  • Expression:  Found in the crab pericardial organs.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Limulus (genus), Limulidae (family), Xiphosura (order), Merostomata (class), Chelicerata (subphylum), Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0008233 peptidase activity; GO:0008236 serine-type peptidase activity; GO:0016787 hydrolase activity
  • GO BP:  GO:0006508 proteolysis; GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  RYLPT
  • Length:  5(1-5)
  • Propeptide:  RYLPT
  • Signal peptide:  NA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Stimulates cardiac output and hindgut motility, modulates visceral and skeletal muscle in many arthropods.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-P62328-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    AF-P62328-F1.pdbhor002910_AF2.pdbhor002910_ESM.pdb

Physical Information

Mass: 72028 Formula: C30H48N8O8
Absent amino acids: ACDEFGHIKMNQSVW Common amino acids: LPRTY
pI: 9.35 Basic residues: 1
Polar residues: 2 Hydrophobic residues: 1
Hydrophobicity: -86 Boman Index: -1271
Half-Life: 1 hour Half-Life Yeast: 2 min
Half-Life E.Coli: 2 min Aliphatic Index 78
Instability Index: 3144 Extinction Coefficient cystines: 1490
Absorbance 280nm: 372.5

Literature

  • PubMed ID:  2356151
  • Title:  Identification of proctolin in the central nervous system of the horseshoe crab, Limulus polyphemus.